Oleg Fedorov
Oleg Fedorov
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Cited by
Selective inhibition of BET bromodomains
P Filippakopoulos, J Qi, S Picaud, Y Shen, WB Smith, O Fedorov, ...
Nature 468 (7327), 1067-1073, 2010
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty Jr, ...
Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006
NMR-based model of a telomerase-inhibiting compound bound to G-quadruplex DNA
OY Fedoroff, M Salazar, H Han, VV Chemeris, SM Kerwin, LH Hurley
Biochemistry 37 (36), 12367-12374, 1998
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
S Picaud, C Wells, I Felletar, D Brotherton, S Martin, P Savitsky, ...
Proceedings of the National Academy of Sciences 110 (49), 19754-19759, 2013
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
O Fedorov, B Marsden, V Pogacic, P Rellos, S Müller, AN Bullock, ...
Proceedings of the National Academy of Sciences 104 (51), 20523-20528, 2007
Dual kinase-bromodomain inhibitors for rationally designed polypharmacology
P Ciceri, S Müller, A O'mahony, O Fedorov, P Filippakopoulos, JP Hunt, ...
Nature chemical biology 10 (4), 305-312, 2014
The (un) targeted cancer kinome
O Fedorov, S Müller, S Knapp
Nature chemical biology 6 (3), 166-169, 2010
Structure of a DNA: RNA hybrid duplex: why RNase H does not cleave pure RNA
OY Fedoroff, M Salazar, BR Reid
Journal of molecular biology 233 (3), 509-523, 1993
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains
DA Hay, O Fedorov, S Martin, DC Singleton, C Tallant, C Wells, S Picaud, ...
Journal of the American Chemical Society 136 (26), 9308-9319, 2014
G-quadruplexes as targets for drug design
LH Hurley, RT Wheelhouse, D Sun, SM Kerwin, M Salazar, OY Fedoroff, ...
Pharmacology & therapeutics 85 (3), 141-158, 2000
PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains
S Picaud, D Da Costa, A Thanasopoulou, P Filippakopoulos, PV Fish, ...
Cancer research 73 (11), 3336-3346, 2013
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses
A Hammitzsch, C Tallant, O Fedorov, A O’Mahony, PE Brennan, DA Hay, ...
Proceedings of the National Academy of Sciences 112 (34), 10768-10773, 2015
3, 5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
DS Hewings, M Wang, M Philpott, O Fedorov, S Uttarkar, ...
Journal of medicinal chemistry 54 (19), 6761-6770, 2011
Rapid covalent-probe discovery by electrophile-fragment screening
E Resnick, A Bradley, J Gan, A Douangamath, T Krojer, R Sethi, ...
Journal of the American Chemical Society 141 (22), 8951-8968, 2019
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit
PV Fish, P Filippakopoulos, G Bish, PE Brennan, ME Bunnage, AS Cook, ...
Journal of medicinal chemistry 55 (22), 9831-9837, 2012
Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule
A Rangan, OY Fedoroff, LH Hurley
Journal of Biological Chemistry 276 (7), 4640-4646, 2001
Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy
S Picaud, O Fedorov, A Thanasopoulou, K Leonards, K Jones, J Meier, ...
Cancer research 75 (23), 5106-5119, 2015
Structural analysis identifies imidazo [1, 2-b] pyridazines as PIM kinase inhibitors with in vitro antileukemic activity
V Pogacic, AN Bullock, O Fedorov, P Filippakopoulos, C Gasser, A Biondi, ...
Cancer research 67 (14), 6916-6924, 2007
Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing
O Fedorov, K Huber, A Eisenreich, P Filippakopoulos, O King, AN Bullock, ...
Chemistry & biology 18 (1), 67-76, 2011
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein α-subunits
M Soundararajan, FS Willard, AJ Kimple, AP Turnbull, LJ Ball, GA Schoch, ...
Proceedings of the National Academy of Sciences 105 (17), 6457-6462, 2008
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