An acylation cycle regulates localization and activity of palmitoylated Ras isoforms O Rocks, A Peyker, M Kahms, PJ Verveer, C Koerner, M Lumbierres, ... Science 307 (5716), 1746-1752, 2005 | 1005 | 2005 |
Fluorogenic probes for live-cell imaging of the cytoskeleton G Lukinavičius, L Reymond, E D'este, A Masharina, F Göttfert, H Ta, ... Nature methods 11 (7), 731-733, 2014 | 896 | 2014 |
Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation A Hakkim, TA Fuchs, NE Martinez, S Hess, H Prinz, A Zychlinsky, ... Nature chemical biology 7 (2), 75-77, 2011 | 812 | 2011 |
The Pictet–Spengler reaction in nature and in organic chemistry J Stöckigt, AP Antonchick, F Wu, H Waldmann Angewandte Chemie International Edition 50 (37), 8538-8564, 2011 | 738 | 2011 |
From protein domains to drug candidates—natural products as guiding principles in the design and synthesis of compound libraries R Breinbauer, IR Vetter, H Waldmann Angewandte Chemie International Edition 41 (16), 2878-2890, 2002 | 711 | 2002 |
Chemical strategies for generating protein biochips P Jonkheijm, D Weinrich, H Schröder, CM Niemeyer, H Waldmann Angewandte Chemie International Edition 47 (50), 9618-9647, 2008 | 709 | 2008 |
Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling G Zimmermann, B Papke, S Ismail, N Vartak, A Chandra, M Hoffmann, ... Nature 497 (7451), 638-642, 2013 | 708 | 2013 |
Charting biologically relevant chemical space: a structural classification of natural products (SCONP) MA Koch, A Schuffenhauer, M Scheck, S Wetzel, M Casaulta, A Odermatt, ... Proceedings of the National Academy of Sciences 102 (48), 17272-17277, 2005 | 690 | 2005 |
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis G Siegel, G Obernosterer, R Fiore, M Oehmen, S Bicker, M Christensen, ... Nature cell biology 11 (6), 705-716, 2009 | 592 | 2009 |
Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products AP Antonchick, C Gerding-Reimers, M Catarinella, M Schürmann, H Preut, ... Nature chemistry 2 (9), 735-740, 2010 | 581 | 2010 |
Biology‐oriented synthesis S Wetzel, RS Bon, K Kumar, H Waldmann Angewandte Chemie International Edition 50 (46), 10800-10826, 2011 | 563 | 2011 |
Target identification for small bioactive molecules: finding the needle in the haystack S Ziegler, V Pries, C Hedberg, H Waldmann Angewandte Chemie International Edition 52 (10), 2744-2792, 2013 | 527 | 2013 |
Inhibitors of protein tyrosine phosphatases: Next‐generation drugs? L Bialy, H Waldmann Angewandte Chemie International Edition 44 (25), 3814-3839, 2005 | 506 | 2005 |
The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins O Rocks, M Gerauer, N Vartak, S Koch, ZP Huang, M Pechlivanis, ... Cell 141 (3), 458-471, 2010 | 496 | 2010 |
Protecting group strategies in organic synthesis M Schelhaas, H Waldmann Angewandte Chemie International Edition in English 35 (18), 2056-2083, 1996 | 482 | 1996 |
Catalytic enantioselective 1, 3-dipolar cycloadditions of azomethine ylides for biology-oriented synthesis R Narayan, M Potowski, ZJ Jia, AP Antonchick, H Waldmann Accounts of Chemical Research 47 (4), 1296-1310, 2014 | 472 | 2014 |
Charting, navigating, and populating natural product chemical space for drug discovery H Lachance, S Wetzel, K Kumar, H Waldmann Journal of medicinal chemistry 55 (13), 5989-6001, 2012 | 442 | 2012 |
Small-molecule inhibition of APT1 affects Ras localization and signaling FJ Dekker, O Rocks, N Vartak, S Menninger, C Hedberg, R Balamurugan, ... Nature chemical biology 6 (6), 449-456, 2010 | 423 | 2010 |
The scaffold tree− visualization of the scaffold universe by hierarchical scaffold classification A Schuffenhauer, P Ertl, S Roggo, S Wetzel, MA Koch, H Waldmann Journal of chemical information and modeling 47 (1), 47-58, 2007 | 416 | 2007 |
New modalities for challenging targets in drug discovery E Valeur, SM Guéret, H Adihou, R Gopalakrishnan, M Lemurell, ... Angewandte Chemie International Edition 56 (35), 10294-10323, 2017 | 377 | 2017 |