| Phenylalanine-508 mediates a cytoplasmic–membrane domain contact in the CFTR 3D structure crucial to assembly and channel function AWR Serohijos, T Hegedűs, AA Aleksandrov, L He, L Cui, NV Dokholyan, ... Proceedings of the National Academy of Sciences 105 (9), 3256-3261, 2008 | 439 | 2008 |
| Mechanism-based corrector combination restores ΔF508-CFTR folding and function T Okiyoneda, G Veit, JF Dekkers, M Bagdany, N Soya, H Xu, A Roldan, ... Nature chemical biology 9 (7), 444, 2013 | 414 | 2013 |
| High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter C Özvegy-Laczka, T Hegedűs, G Várady, O Ujhelly, JD Schuetz, A Varadi, ... Molecular pharmacology 65 (6), 1485-1495, 2004 | 397 | 2004 |
| Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression G Veit, RG Avramescu, D Perdomo, PW Phuan, M Bagdany, PM Apaja, ... Science translational medicine 6 (246), 246ra97-246ra97, 2014 | 303 | 2014 |
| Membrane topology and glycosylation of the human multidrug resistance-associated protein É Bakos, T Hegedüs, Z Holló, E Welker, GE Tusnády, GJR Zaman, ... Journal of Biological Chemistry 271 (21), 12322-12326, 1996 | 271 | 1996 |
| Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1 T Hegedűs, L Őrfi, A Seprődi, A Váradi, B Sarkadi, G Kéri Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1587 (2-3 …, 2002 | 244 | 2002 |
| Domain interdependence in the biosynthetic assembly of CFTR L Cui, L Aleksandrov, XB Chang, YX Hou, L He, T Hegedus, M Gentzsch, ... Journal of molecular biology 365 (4), 981-994, 2007 | 243 | 2007 |
| Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells Z Holló, L Homolya, T Hegedüs, B Sarkadi FEBS letters 383 (1-2), 99-104, 1996 | 234 | 1996 |
| HAEdb: A novel interactive, locus‐specific mutation database for the C1 inhibitor gene L Kalmár, T Hegedüs, H Farkas, M Nagy, A Tordai Human mutation 25 (1), 1-5, 2005 | 136 | 2005 |
| Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating L He, AA Aleksandrov, AWR Serohijos, T Hegedüs, LA Aleksandrov, ... Journal of Biological Chemistry 283 (39), 26383-26390, 2008 | 130 | 2008 |
| Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance? A Brózik, C Hegedüs, Z Erdei, T Hegedűs, C Özvegy-Laczka, G Szakács, ... Expert opinion on drug metabolism & toxicology 7 (5), 623-642, 2011 | 126 | 2011 |
| C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins T Hegedüs, T Sessler, R Scott, W Thelin, É Bakos, A Váradi, K Szabó, ... Biochemical and biophysical research communications 302 (3), 454-461, 2003 | 118 | 2003 |
| Nucleotide Occlusion in the Human Cystic Fibrosis Transmembrane Conductance Regulator DIFFERENT PATTERNS IN THE TWO NUCLEOTIDE BINDING DOMAINS K Szabó, G Szakács, T Hegedűs, B Sarkadi Journal of Biological Chemistry 274 (18), 12209-12212, 1999 | 102 | 1999 |
| Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A T Hegedűs, A Aleksandrov, A Mengos, L Cui, TJ Jensen, JR Riordan Biochimica et Biophysica Acta (BBA)-Biomembranes 1788 (6), 1341-1349, 2009 | 78 | 2009 |
| F508del CFTR with two altered RXR motifs escapes from ER quality control but its channel activity is thermally sensitive T Hegedűs, A Aleksandrov, L Cui, M Gentzsch, XB Chang, JR Riordan Biochimica et Biophysica Acta (BBA)-Biomembranes 1758 (5), 565-572, 2006 | 67 | 2006 |
| Computational studies reveal phosphorylation-dependent changes in the unstructured R domain of CFTR T Hegedűs, AWR Serohijos, NV Dokholyan, L He, JR Riordan Journal of molecular biology 378 (5), 1052-1063, 2008 | 65 | 2008 |
| Effects of the lipid environment, cholesterol and bile acids on the function of the purified and reconstituted human ABCG2 protein Á Telbisz, C Özvegy-Laczka, T Hegedűs, A Váradi, B Sarkadi Biochemical Journal 450 (2), 387-395, 2013 | 60 | 2013 |
| ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions G Gyimesi, S Ramachandran, P Kota, NV Dokholyan, B Sarkadi, ... Biochimica et Biophysica Acta (BBA)-Biomembranes 1808 (12), 2954-2964, 2011 | 55 | 2011 |
| Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter C Özvegy-Laczka, R Laczkó, C Hegedűs, T Litman, G Várady, K Goda, ... Journal of Biological Chemistry 283 (38), 26059-26070, 2008 | 55 | 2008 |
| Diminished self-chaperoning activity of the ΔF508 mutant of CFTR results in protein misfolding AWR Serohijos, T Hegedűs, JR Riordan, NV Dokholyan PLoS Comput Biol 4 (2), e1000008, 2008 | 54 | 2008 |
