Michael Costanzo

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Charles BooneProfessor, Donnelly Centre, University of TorontoVerified email at utoronto.ca
Chad MyersUniversity of MinnesotaVerified email at umn.edu
Anastasia BaryshnikovaPrincipal Investigator, Calico Life SciencesVerified email at calicolabs.com
Corey NislowProfessor, CRC Tier 1 in Translational Genomics, University of British ColumbiaVerified email at ubc.ca
Jason MoffatSenior Scientist & Program Head, Genetics & Genome Biology, Sickkids Hospital; Professor, UofTVerified email at utoronto.ca
Benjamin VanderSluisDirector, Data Driven Solutions, HarrisVerified email at bjv.us
Grant W BrownUniversity of TorontoVerified email at utoronto.ca
Guri Nina GiaeverAssociate Professor, Faculty of Pharmaceutical Sciences, University of British ColumbiaVerified email at UBC.ca
Gary BaderProfessor of Molecular Genetics and Computer Science, The Donnelly Centre, University of TorontoVerified email at utoronto.ca
Judice KohDept of Biomedical Informatics, Yong Loo Lin School of Medicine, National University of SingaporeVerified email at nus.edu.sg
Jeremy BellayVerified email at umiacs.umd.edu
Frederick P (Fritz) RothUniversity of Pittsburgh School of Medicine, Department of Computational & Systems BiologyVerified email at pitt.edu
anne-claude gingrasLunenfeld-Tanenbaum Research Institute; University of TorontoVerified email at lunenfeld.ca
Magali MichautDanStem, Copenhagen University, DenmarkVerified email at sund.ku.dk
Balázs PappBiological Research Centre & HCEMM, Szeged, HungaryVerified email at brc.hu
Raamesh DeshpandeUniversity of MinnesotaVerified email at cs.umn.edu
Olga TroyanskayaPrinceton University and Flatiron Institute, Simons FoundationVerified email at princeton.edu
Philip M. KimProfessor, University of TorontoVerified email at kimlab.org
Walid HouryProfessor of Biochemistry, University of TorontoVerified email at utoronto.ca
Andrew M. SmithVice President at Klick HealthVerified email at utoronto.ca

Michael Costanzo

university of toronto

Verified email at utoronto.ca

functional genomics


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The genetic landscape of a cell M Costanzo, A Baryshnikova, J Bellay, Y Kim, ED Spear, CS Sevier, ... science 327 (5964), 425-431, 2010	2543	2010
A global genetic interaction network maps a wiring diagram of cellular function M Costanzo, B VanderSluis, EN Koch, A Baryshnikova, C Pons, G Tan, ... Science 353 (6306), aaf1420, 2016	1315	2016
Widespread expansion of protein interaction capabilities by alternative splicing X Yang, J Coulombe-Huntington, S Kang, GM Sheynkman, T Hao, ... Cell 164 (4), 805-817, 2016	583	2016
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress JM Tkach, A Yimit, AY Lee, M Riffle, M Costanzo, D Jaschob, JA Hendry, ... Nature cell biology 14 (9), 966-976, 2012	582	2012
CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast M Costanzo, JL Nishikawa, X Tang, JS Millman, O Schub, K Breitkreuz, ... Cell 117 (7), 899-913, 2004	580	2004
Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens T Hart, AHY Tong, K Chan, J Van Leeuwen, A Seetharaman, M Aregger, ... G3: Genes, Genomes, Genetics 7 (8), 2719-2727, 2017	538	2017
Systematic exploration of essential yeast gene function with temperature-sensitive mutants Z Li, FJ Vizeacoumar, S Bahr, J Li, J Warringer, FS Vizeacoumar, R Min, ... Nature biotechnology 29 (4), 361-367, 2011	454	2011
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale A Baryshnikova, M Costanzo, Y Kim, H Ding, J Koh, K Toufighi, JY Youn, ... Nature methods 7 (12), 1017-1024, 2010	437	2010
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast TF Menne, B Goyenechea, N Sánchez-Puig, CC Wong, LM Tonkin, ... Nature genetics 39 (4), 486-495, 2007	379	2007
Systematic exploration of synergistic drug pairs M Cokol, HN Chua, M Tasan, B Mutlu, ZB Weinstein, Y Suzuki, ME Nergiz, ... Molecular systems biology 7 (1), 544, 2011	367	2011
Systematic mapping of genetic interaction networks SJ Dixon, M Costanzo, A Baryshnikova, B Andrews, C Boone Annual review of genetics 43 (1), 601-625, 2009	355	2009
Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome AJ Finch, C Hilcenko, N Basse, LF Drynan, B Goyenechea, TF Menne, ... Genes & development 25 (9), 917-929, 2011	327	2011
Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA S Leidel, PGA Pedrioli, T Bucher, R Brost, M Costanzo, A Schmidt, ... Nature 458 (7235), 228-232, 2009	319	2009
Systematic analysis of complex genetic interactions E Kuzmin, B VanderSluis, W Wang, G Tan, R Deshpande, Y Chen, M Usaj, ... Science 360 (6386), eaao1729, 2018	290	2018
Synthetic genetic array (SGA) analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe A Baryshnikova, M Costanzo, S Dixon, FJ Vizeacoumar, CL Myers, ... Methods in enzymology 470, 145-179, 2010	253	2010
Global gene deletion analysis exploring yeast filamentous growth O Ryan, RS Shapiro, CF Kurat, D Mayhew, A Baryshnikova, B Chin, ... Science 337 (6100), 1353-1356, 2012	252	2012
An integrated approach to characterize genetic interaction networks in yeast metabolism B Szappanos, K Kovács, B Szamecz, F Honti, M Costanzo, ... Nature genetics 43 (7), 656-662, 2011	248	2011
The interaction network of the chaperonin CCT C Dekker, PC Stirling, EA McCormack, H Filmore, A Paul, RL Brost, ... The EMBO journal 27 (13), 1827-1839, 2008	237	2008
Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation R Zhao, Y Kakihara, A Gribun, J Huen, G Yang, M Khanna, M Costanzo, ... The Journal of cell biology 180 (3), 563-578, 2008	223	2008
Global genetic networks and the genotype-to-phenotype relationship M Costanzo, E Kuzmin, J van Leeuwen, B Mair, J Moffat, C Boone, ... Cell 177 (1), 85-100, 2019	222	2019

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