| Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion N Wijesekara, FF Dai, AB Hardy, PR Giglou, A Bhattacharjee, V Koshkin, ... Diabetologia 53, 1656-1668, 2010 | 355 | 2010 |
| Characterization of SNARE protein expression in beta cell lines and pancreatic islets MB Wheeler, L Sheu, M Ghai, A Bouquillon, G Grondin, U Weller, ... Endocrinology 137 (4), 1340-1348, 1996 | 262 | 1996 |
| Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients CG Ostenson, H Gaisano, L Sheu, A Tibell, T Bartfai Diabetes 55 (2), 435-440, 2006 | 258 | 2006 |
| Members of the Kv1 and Kv2 Voltage-Dependent K+ Channel Families Regulate Insulin Secretion PE MacDonald, XF Ha, J Wang, SR Smukler, AM Sun, HY Gaisano, ... Molecular endocrinology 15 (8), 1423-1435, 2001 | 241 | 2001 |
| Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells. HY Gaisano, M Ghai, PN Malkus, L Sheu, A Bouquillon, MK Bennett, ... Molecular biology of the cell 7 (12), 2019-2027, 1996 | 217 | 1996 |
| Disruption of pancreatic β-cell lipid rafts modifies Kv2. 1 channel gating and insulin exocytosis F Xia, X Gao, E Kwan, PPL Lam, L Chan, K Sy, L Sheu, MB Wheeler, ... Journal of Biological Chemistry 279 (23), 24685-24691, 2004 | 212 | 2004 |
| Caspase-3-dependent β-cell apoptosis in the initiation of autoimmune diabetes mellitus N Liadis, K Murakami, M Eweida, AR Elford, L Sheu, HY Gaisano, ... Molecular and cellular biology 25 (9), 3620-3629, 2005 | 196 | 2005 |
| Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice BJ Lamont, Y Li, E Kwan, TJ Brown, H Gaisano, DJ Drucker The Journal of clinical investigation 122 (1), 388-402, 2012 | 192 | 2012 |
| Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic β-cells F Xia, L Xie, A Mihic, X Gao, Y Chen, HY Gaisano, RG Tsushima Endocrinology 149 (10), 5136-5145, 2008 | 187 | 2008 |
| New insights into the mechanisms of pancreatitis HY Gaisano, FS Gorelick Gastroenterology 136 (7), 2040-2044, 2009 | 162 | 2009 |
| Erythropoietin protects against diabetes through direct effects on pancreatic β cells D Choi, SA Schroer, SY Lu, L Wang, X Wu, Y Liu, Y Zhang, HY Gaisano, ... Journal of Experimental Medicine 207 (13), 2831-2842, 2010 | 160 | 2010 |
| Gut-associated IgA+ immune cells regulate obesity-related insulin resistance H Luck, S Khan, JH Kim, JK Copeland, XS Revelo, S Tsai, M Chakraborty, ... Nature communications 10 (1), 3650, 2019 | 156 | 2019 |
| α/β-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion S Zhao, Y Mugabo, J Iglesias, L Xie, V Delghingaro-Augusto, R Lussier, ... Cell metabolism 19 (6), 993-1007, 2014 | 156 | 2014 |
| Tetanus toxin light chain cleaves a vesicle-associated membrane protein (VAMP) isoform 2 in rat pancreatic zymogen granules and inhibits enzyme secretion. HY Gaisano, L Sheu, JK Foskett, WS Trimble Journal of Biological Chemistry 269 (25), 17062-17066, 1994 | 156 | 1994 |
| Syntaxin 1A binds to the cytoplasmic C terminus of Kv2. 1 to regulate channel gating and trafficking YM Leung, Y Kang, X Gao, F Xia, H Xie, L Sheu, S Tsuk, I Lotan, ... Journal of Biological Chemistry 278 (19), 17532-17538, 2003 | 152 | 2003 |
| Regulation of insulin exocytosis by Munc13-1 L Sheu, EA Pasyk, J Ji, X Huang, X Gao, F Varoqueaux, N Brose, ... Journal of Biological Chemistry 278 (30), 27556-27563, 2003 | 150 | 2003 |
| SNAREing Voltage-Gated K+ and ATP-Sensitive K+ Channels: Tuning β-Cell Excitability with Syntaxin-1A and Other Exocytotic Proteins YM Leung, EP Kwan, B Ng, Y Kang, HY Gaisano Endocrine reviews 28 (6), 653-663, 2007 | 121 | 2007 |
| Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance EP Kwan, L Xie, L Sheu, CJ Nolan, M Prentki, A Betz, N Brose, ... Diabetes 55 (5), 1421-1429, 2006 | 118 | 2006 |
| Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by … HY Gaisano, CG Ostenson, L Sheu, MB Wheeler, S Efendic Endocrinology 143 (11), 4218-4226, 2002 | 115 | 2002 |
| VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis LI Cosen-Binker, MG Binker, CC Wang, W Hong, HY Gaisano The Journal of clinical investigation 118 (7), 2535-2551, 2008 | 114 | 2008 |
william trimbleSenior Scientist, Cell Biology Program, Hospital for Sick ChildrenVerified email at sickkids.ca
