Rui M M Brito
Rui M M Brito
Associate Professor, Chemistry Department, University of Coimbra
Preverjeni e-poštni naslov na ci.uc.pt - Domača stran
Tetramer dissociation and monomer partial unfolding precedes protofibril formation in amyloidogenic transthyretin variants
A Quintas, DC Vaz, I Cardoso, MJM Saraiva, RMM Brito
Journal of Biological Chemistry 276 (29), 27207-27213, 2001
Determination of the critical micelle concentration of surfactants using the fluorescent probe N-phenyl-1-naphthylamine
RMM Brito, WLC Vaz
Analytical biochemistry 152 (2), 250-255, 1986
The tetrameric protein transthyretin dissociates to a non-native monomer in solution: a novel model for amyloidogenesis
A Quintas, MJM Saraiva, RMM Brito
Journal of Biological Chemistry 274 (46), 32943-32949, 1999
Structure and aggregation mechanisms in amyloids
ZL Almeida, RMM Brito
Molecules 25 (5), 1195, 2020
The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution
A Quintas, MJM Saraiva, RMM Brito
Febs Letters 418 (3), 297-300, 1997
The saposin-like domain of the plant aspartic proteinase precursor is a potent inducer of vesicle leakage
C Egas, N Lavoura, R Resende, RMM Brito, E Pires, MCP de Lima, ...
Journal of Biological Chemistry 275 (49), 38190-38196, 2000
Structural characterization of the minimal segment of TDP-43 competent for aggregation
M Mompeán, E Buratti, C Guarnaccia, RMM Brito, A Chakrabartty, ...
Archives of biochemistry and biophysics 545, 53-62, 2014
Evaluation by fluorescence, STD-NMR, docking and semi-empirical calculations of the o-NBA photo-acid interaction with BSA
OA Chaves, CSH Jesus, PF Cruz, CMR Sant'Anna, RMM Brito, C Serpa
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 169, 175-181, 2016
Mining approximate motifs in time series
PG Ferreira, PJ Azevedo, CG Silva, RMM Brito
Discovery Science: 9th International Conference, DS 2006, Barcelona, Spain …, 2006
Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I,
GMC Gasmi-Seabrook, JW Howarth, N Finley, E Abusamhadneh, ...
Biochemistry 38 (26), 8313-8322, 1999
Ligand-targeted delivery of photosensitizers for cancer treatment
P Gierlich, AI Mata, C Donohoe, RMM Brito, MO Senge, ...
Molecules 25 (22), 5317, 2020
Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin
VL Shnyrov, E Villar, GG Zhadan, JM Sanchez-Ruiz, A Quintas, ...
Biophysical Chemistry 88 (1-3), 61-67, 2000
Enthalpic and entropic contributions mediate the role of disulfide bonds on the conformational stability of Interleukin‐4
DC Vaz, JR Rodrigues, W Sebald, CM Dobson, RMM Brito
Protein science 15 (1), 33-44, 2006
A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model
TQ Faria, ZL Almeida, PF Cruz, CSH Jesus, P Castanheira, RMM Brito
Physical Chemistry Chemical Physics 17 (11), 7255-7263, 2015
The low-affinity Ca2 (+)-binding sites in cardiac/slow skeletal muscle troponin C perform distinct functions: site I alone cannot trigger contraction.
HL Sweeney, RM Brito, PR Rosevear, JA Putkey
Proceedings of the National Academy of Sciences 87 (24), 9538-9542, 1990
The central role of non-structural protein 1 (NS1) in influenza biology and infection
N Rosário-Ferreira, AJ Preto, R Melo, IS Moreira, RMM Brito
International Journal of Molecular Sciences 21 (4), 1511, 2020
Changes in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channel
CA Harley, CSH Jesus, R Carvalho, RMM Brito, JH Morais-Cabral
PloS one 7 (3), e32654, 2012
A serpin released by an entomopathogen impairs clot formation in insect defense system
D Toubarro, MM Avila, YJ Hao, N Balasubramanian, Y Jing, R Montiel, ...
PloS one 8 (7), e69161, 2013
The apoptogenic toxin AIP56 is a metalloprotease AB toxin that cleaves NF-κb P65
DS Silva, LMG Pereira, AR Moreira, F Ferreira-da-Silva, RM Brito, ...
PLoS pathogens 9 (2), e1003128, 2013
Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: insights from molecular dynamics simulations
JR Rodrigues, CJV Simões, CG Silva, RMM Brito
Protein science 19 (2), 202-219, 2010
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