Dr. James D. Johnson, PhD
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
A Rezania, JE Bruin, P Arora, A Rubin, I Batushansky, A Asadi, S O'dwyer, ...
Nature biotechnology 32 (11), 1121-1133, 2014
Hyperinsulinemia drives diet-induced obesity independently of brain insulin production
AE Mehran, NM Templeman, GS Brigidi, GE Lim, KY Chu, X Hu, ...
Cell metabolism 16 (6), 723-737, 2012
β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
LR Brunham, JK Kruit, TD Pape, JM Timmins, AQ Reuwer, Z Vasanji, ...
Nature medicine 13 (3), 340-347, 2007
Increased islet apoptosis in Pdx1+/– mice
JD Johnson, NT Ahmed, DS Luciani, Z Han, H Tran, J Fujita, S Misler, ...
The Journal of clinical investigation 111 (8), 1147-1160, 2003
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet β cells
E Bernal-Mizrachi, S Fatrai, JD Johnson, M Ohsugi, K Otani, Z Han, ...
The Journal of clinical investigation 114 (7), 928-936, 2004
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome
JD Johnson, E Bernal-Mizrachi, EU Alejandro, Z Han, TB Kalynyak, H Li, ...
Proceedings of the National Academy of Sciences 103 (51), 19575-19580, 2006
Effects of palmitate on ER and cytosolic Ca2+ homeostasis in β-cells
KS Gwiazda, TLB Yang, Y Lin, JD Johnson
American Journal of Physiology-Endocrinology and Metabolism 296 (4), E690-E701, 2009
Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and β-cell death
DS Luciani, KS Gwiazda, TLB Yang, TB Kalynyak, Y Bychkivska, ...
Diabetes 58 (2), 422-432, 2009
Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets
JD Johnson, Z Ao, P Ao, H Li, LJ Dai, Z He, M Tee, KJ Potter, AM Klimek, ...
Cell transplantation 18 (8), 833-845, 2009
Carboxypeptidase E mediates palmitate-induced β-cell ER stress and apoptosis
KD Jeffrey, EU Alejandro, DS Luciani, TB Kalynyak, X Hu, H Li, Y Lin, ...
Proceedings of the National Academy of Sciences 105 (24), 8452-8457, 2008
A multi-year analysis of islet transplantation compared with intensive medical therapy on progression of complications in type 1 diabetes
GL Warnock, DM Thompson, RM Meloche, RJ Shapiro, Z Ao, P Keown, ...
Transplantation 86 (12), 1762-1766, 2008
Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells
JD Johnson, S Misler
Proceedings of the National Academy of Sciences 99 (22), 14566-14571, 2002
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
JD Johnson, Z Han, K Otani, H Ye, Y Zhang, H Wu, Y Horikawa, S Misler, ...
Journal of Biological Chemistry 279 (23), 24794-24802, 2004
Reduced insulin production relieves endoplasmic reticulum stress and induces β cell proliferation
M Szabat, MM Page, E Panzhinskiy, S Skovs°, M Mojibian, ...
Cell metabolism 23 (1), 179-193, 2016
Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells
JE Bruin, S Erener, J Vela, X Hu, JD Johnson, HT Kurata, FC Lynn, ...
Stem cell research 12 (1), 194-208, 2014
Insulin stimulates primary β-cell proliferation via Raf-1 kinase
JL Beith, EU Alejandro, JD Johnson
Endocrinology 149 (5), 2251-2260, 2008
Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function
JK Kruit, N Wijesekara, C Westwell-Roper, T Vanmierlo, W De Haan, ...
Diabetes 61 (3), 659-664, 2012
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation
K Fujimoto, PT Hanson, H Tran, EL Ford, Z Han, JD Johnson, RE Schmidt, ...
Journal of Biological Chemistry 284 (40), 27664-27673, 2009
Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, andá…
M Ohsugi, C Cras-MÚneur, Y Zhou, E Bernal-Mizrachi, JD Johnson, ...
Journal of Biological Chemistry 280 (6), 4992-5003, 2005
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