| The promise and peril of chemical probes CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ... Nature chemical biology 11 (8), 536-541, 2015 | 865 | 2015 |
| SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1 M Rebsamen, L Pochini, T Stasyk, MEG De Araújo, M Galluccio, ... Nature 519 (7544), 477-481, 2015 | 706 | 2015 |
| Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy KVM Huber, E Salah, B Radic, M Gridling, JM Elkins, A Stukalov, ... Nature 508 (7495), 222-227, 2014 | 452 | 2014 |
| PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers L Brault, C Gasser, F Bracher, K Huber, S Knapp, J Schwaller haematologica 95 (6), 1004, 2010 | 433 | 2010 |
| Artemisinins target GABAA receptor signaling and impair α cell identity J Li, T Casteels, T Frogne, C Ingvorsen, C Honore, M Courtney, ... Cell 168 (1), 86-100. e15, 2017 | 400 | 2017 |
| Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia F Grebien, M Vedadi, M Getlik, R Giambruno, A Grover, R Avellino, ... Nature chemical biology 11 (8), 571-578, 2015 | 302 | 2015 |
| Rapid covalent-probe discovery by electrophile-fragment screening E Resnick, A Bradley, J Gan, A Douangamath, T Krojer, R Sethi, ... Journal of the American Chemical Society 141 (22), 8951-8968, 2019 | 277 | 2019 |
| Quantitative, wide-spectrum kinase profiling in live cells for assessing the effect of cellular ATP on target engagement JD Vasta, CR Corona, J Wilkinson, CA Zimprich, JR Hartnett, MR Ingold, ... Cell chemical biology 25 (2), 206-214. e11, 2018 | 229 | 2018 |
| Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling KVM Huber, KM Olek, AC Müller, CSH Tan, KL Bennett, J Colinge, ... Nature methods 12 (11), 1055-1057, 2015 | 225 | 2015 |
| Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing O Fedorov, K Huber, A Eisenreich, P Filippakopoulos, O King, AN Bullock, ... Chemistry & biology 18 (1), 67-76, 2011 | 224 | 2011 |
| A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis A Fauster, M Rebsamen, KVM Huber, JW Bigenzahn, A Stukalov, ... Cell death & disease 6 (5), e1767-e1767, 2015 | 196 | 2015 |
| The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity GE Winter, B Radic, C Mayor-Ruiz, VA Blomen, C Trefzer, RK Kandasamy, ... Nature chemical biology 10 (9), 768-773, 2014 | 182 | 2014 |
| Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action MV Babak, SM Meier, KVM Huber, J Reynisson, AA Legin, MA Jakupec, ... Chemical science 6 (4), 2449-2456, 2015 | 166 | 2015 |
| Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site E Hadzijusufovic, K Albrecht-Schgoer, K Huber, G Hoermann, F Grebien, ... Leukemia 31 (11), 2388-2397, 2017 | 143 | 2017 |
| Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions R Martins, J Maier, AD Gorki, KVM Huber, O Sharif, P Starkl, S Saluzzo, ... Nature immunology 17 (12), 1361-1372, 2016 | 143 | 2016 |
| A chemical biology toolbox to study protein methyltransferases and epigenetic signaling S Scheer, S Ackloo, TS Medina, M Schapira, F Li, JA Ward, AM Lewis, ... Nature communications 10 (1), 19, 2019 | 121 | 2019 |
| Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma U Weirauch, N Beckmann, M Thomas, A Grünweller, K Huber, F Bracher, ... Neoplasia 15 (7), 783-IN28, 2013 | 119 | 2013 |
| Discovery of a PCAF bromodomain chemical probe M Moustakim, PGK Clark, L Trulli, AL Fuentes de Arriba, MT Ehebauer, ... Angewandte Chemie 129 (3), 845-849, 2017 | 93 | 2017 |
| Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3 J Böttcher, D Dilworth, U Reiser, RA Neumüller, M Schleicher, ... Nature chemical biology 15 (8), 822-829, 2019 | 92 | 2019 |
| Quantifying CDK inhibitor selectivity in live cells CI Wells, JD Vasta, CR Corona, J Wilkinson, CA Zimprich, MR Ingold, ... Nature communications 11 (1), 2743, 2020 | 89 | 2020 |
Giulio Superti-FurgaScientific Director, CeMM Research Center for Molecular Medicine of the Austrian Academy ofVerified email at cemm.oeaw.ac.at
