Martin JINEK
Martin JINEK
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A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity
M Jinek, K Chylinski, I Fonfara, M Hauer, JA Doudna, E Charpentier
science 337 (6096), 816-821, 2012
RNA-programmed genome editing in human cells
M Jinek, A East, A Cheng, S Lin, E Ma, J Doudna
elife 2, e00471, 2013
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
SH Sternberg, S Redding, M Jinek, EC Greene, JA Doudna
Biophysical Journal 106 (2), 695a, 2014
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
C Anders, O Niewoehner, A Duerst, M Jinek
Nature 513 (7519), 569-573, 2014
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation
M Jinek, F Jiang, DW Taylor, SH Sternberg, E Kaya, E Ma, C Anders, ...
Science 343 (6176), 1247997, 2014
Sequence-and structure-specific RNA processing by a CRISPR endonuclease
RE Haurwitz, M Jinek, B Wiedenheft, K Zhou, JA Doudna
Science 329 (5997), 1355-1358, 2010
A three-dimensional view of the molecular machinery of RNA interference
M Jinek, JA Doudna
nature 457 (7228), 405-412, 2009
A prudent path forward for genomic engineering and germline gene modification
D Baltimore, P Berg, M Botchan, D Carroll, RA Charo, G Church, JE Corn, ...
Science 348 (6230), 36-38, 2015
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
JA Doudna, M Jinek, E Charpentier, K Chylinski
US Patent 10,266,850, 2019
Structural biology of nucleocytoplasmic transport
A Cook, F Bono, M Jinek, E Conti
Annu. Rev. Biochem. 76, 647-671, 2007
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation
MR Fabian, G Mathonnet, T Sundermeier, H Mathys, JT Zipprich, ...
Molecular cell 35 (6), 868-880, 2009
Structural basis for guide RNA processing and seed-dependent DNA targeting by CRISPR-Cas12a
DC Swarts, J van der Oost, M Jinek
Molecular cell 66 (2), 221-233. e4, 2017
Structural insights into the molecular mechanism of the m6A writer complex
P ¦ledĽ, M Jinek
elife 5, e18434, 2016
Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers
O Niewoehner, C Garcia-Doval, JT Rostøl, C Berk, F Schwede, L Bigler, ...
Nature 548 (7669), 543-548, 2017
The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin α
M Jinek, J Rehwinkel, BD Lazarus, E Izaurralde, JA Hanover, E Conti
Nature structural & molecular biology 11 (10), 1001-1007, 2004
An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3
DG Sashital, M Jinek, JA Doudna
Nature structural & molecular biology 18 (6), 680-687, 2011
Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense
B Wiedenheft, K Zhou, M Jinek, SM Coyle, W Ma, JA Doudna
Structure 17 (6), 904-912, 2009
Mechanistic Insights into the cis-and trans-Acting DNase Activities of Cas12a
DC Swarts, M Jinek
Molecular cell 73 (3), 589-600. e4, 2019
Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes
A Burger, H Lindsay, A Felker, C Hess, C Anders, E Chiavacci, J Zaugg, ...
Development 143 (11), 2025-2037, 2016
Endoribonuclease compositions and methods of use thereof
RE Haurwitz, JA Doudna, B Wiedenheft, M Jinek
US Patent 9,115,348, 2015
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