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Kamila J. Pacholarz
Kamila J. Pacholarz
Verified email at astrazeneca.com
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Cited by
Cited by
Year
Mass spectrometry based tools to investigate protein–ligand interactions for drug discovery
KJ Pacholarz, RA Garlish, RJ Taylor, PE Barran
Chemical Society Reviews 41 (11), 4335-4355, 2012
1592012
Dynamics of Intact Immunoglobulin G Explored by Drift‐Tube Ion‐Mobility Mass Spectrometry and Molecular Modeling
KJ Pacholarz, M Porrini, RA Garlish, RJ Burnley, RJ Taylor, AJ Henry, ...
Angewandte Chemie International Edition 53 (30), 7765-7769, 2014
1072014
A mass-spectrometry-based framework to define the extent of disorder in proteins
R Beveridge, S Covill, KJ Pacholarz, JMD Kalapothakis, CE MacPhee, ...
Analytical chemistry 86 (22), 10979-10991, 2014
1062014
Use of a charge reducing agent to enable intact mass analysis of cysteine-linked antibody-drug-conjugates by native mass spectrometry
KJ Pacholarz, PE Barran
EuPA Open Proteomics 11, 23-27, 2016
482016
Distinguishing Loss of Structure from Subunit Dissociation for Protein Complexes with Variable Temperature Ion Mobility Mass Spectrometry
KJ Pacholarz, PE Barran
Analytical chemistry 87 (12), 6271-6279, 2015
442015
Insights into the Conformations of Three Structurally Diverse Proteins: Cytochrome c, p53, and MDM2, Provided by Variable-Temperature Ion Mobility Mass …
ER Dickinson, E Jurneczko, KJ Pacholarz, DJ Clarke, M Reeves, KL Ball, ...
Analytical chemistry 87 (6), 3231-3238, 2015
442015
Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes
SR Sayers, RL Beavil, NHF Fine, GC Huang, P Choudhary, KJ Pacholarz, ...
Diabetologia 63, 313-323, 2020
352020
Hybrid mass spectrometry methods reveal lot-to-lot differences and delineate the effects of glycosylation on the tertiary structure of Herceptin®
R Upton, LG Migas, KJ Pacholarz, RG Beniston, S Estdale, D Firth, ...
Chemical Science 10 (9), 2811-2820, 2019
322019
Molecular Insights into the Thermal Stability of mAbs with Variable‐Temperature Ion‐Mobility Mass Spectrometry
KJ Pacholarz, SJ Peters, RA Garlish, AJ Henry, RJ Taylor, DP Humphreys, ...
ChemBioChem 17 (1), 46-51, 2016
302016
Charge mediated compaction and rearrangement of gas-phase proteins: a case study considering two proteins at opposing ends of the structure-disorder continuum
JR Jhingree, B Bellina, KJ Pacholarz, PE Barran
Journal of The American Society for Mass Spectrometry 28 (7), 1450-1461, 2017
232017
Hybrid mass spectrometry approaches to determine how L-histidine feedback regulates the enzyzme MtATP-phosphoribosyltransferase
KJ Pacholarz, RJ Burnley, TA Jowitt, V Ordsmith, JP Pisco, M Porrini, ...
Structure 25 (5), 730-738. e4, 2017
232017
Uncoupling conformational states from activity in an allosteric enzyme
JP Pisco, C De Chiara, KJ Pacholarz, A Garza-Garcia, RW Ogrodowicz, ...
Nature communications 8 (1), 203, 2017
212017
MhuD from Mycobacterium tuberculosis: Probing a Dual Role in Heme Storage and Degradation
SJ Matthews, KJ Pacholarz, AP France, TA Jowitt, S Hay, PE Barran, ...
ACS Infectious Diseases 5 (11), 1855-1866, 2019
122019
Characterization of the structure and interactions of P450 BM3 using hybrid mass spectrometry approaches
LN Jeffreys, KJ Pacholarz, LO Johannissen, HM Girvan, PE Barran, ...
Journal of Biological Chemistry 295 (22), 7595-7607, 2020
102020
Reference protocol to assess analytical performance of higher order structural analysis measurements: results from an interlaboratory comparison
K Groves, AE Ashcroft, A Cryar, A Sula, BA Wallace, BB Stocks, C Burns, ...
Analytical Chemistry 93 (26), 9041-9048, 2021
32021
Biochemical characterisation of class III biotin protein ligases from Botrytis cinerea and Zymoseptoria tritici
LM Sternicki, S Nguyen, KJ Pacholarz, P Barran, NR Pendini, GW Booker, ...
Archives of Biochemistry and Biophysics 691, 108509, 2020
22020
Investigation of large protein and multimeric protein complex structures with mass spectrometry techniques
KJ Pacholarz
The University of Edinburgh, 2015
12015
The Application of Mass Spectrometry for the Characterization of Monoclonal Antibody‐Based Therapeutics
R Upton, KJ Pacholarz, D Firth, S Estdale, PE Barran
Analysis of Protein Post‐Translational Modifications by Mass Spectrometry …, 2016
2016
EXAMINING THE M/Z SEPARATIVE CAPABILITY OF TRAVELLING WAVES FOR LARGE MOLECULE CHARACTERISATION
J Ujma, D Langridge, K Richardson, K Pacholarz, E Liggett, J Wildgoose, ...
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Articles 1–19