Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program AL Shaffer, KI Lin, TC Kuo, X Yu, EM Hurt, A Rosenwald, JM Giltnane, ... Immunity 17 (1), 51-62, 2002 | 1332 | 2002 |
Blimp-1-Dependent Repression of Pax-5 Is Required for Differentiation of B Cells to Immunoglobulin M-Secreting Plasma Cells KI Lin, C Angelin-Duclos, TC Kuo, K Calame Molecular and cellular biology 22 (13), 4771-4780, 2002 | 579 | 2002 |
Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR SM Ranuncolo, JM Polo, J Dierov, M Singer, T Kuo, J Greally, R Green, ... Nature immunology 8 (7), 705-714, 2007 | 347 | 2007 |
Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis A Palanichamy, L Apeltsin, TC Kuo, M Sirota, S Wang, SJ Pitts, ... Science translational medicine 6 (248), 248ra106-248ra106, 2014 | 261 | 2014 |
B cell exchange across the blood-brain barrier in multiple sclerosis HC von Büdingen, TC Kuo, M Sirota, CJ Van Belle, L Apeltsin, J Glanville, ... The Journal of clinical investigation 122 (12), 4533-4543, 2012 | 260 | 2012 |
Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation J Glanville, TC Kuo, HC von Büdingen, L Guey, J Berka, PD Sundar, ... Proceedings of the National Academy of Sciences 108 (50), 20066-20071, 2011 | 257 | 2011 |
B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites TC Kuo, KL Calame The Journal of Immunology 173 (9), 5556-5563, 2004 | 173 | 2004 |
Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication J Theruvath, M Menard, BAH Smith, MH Linde, GL Coles, GN Dalton, ... Nature medicine 28 (2), 333-344, 2022 | 161 | 2022 |
ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile SE Kauder, TC Kuo, O Harrabi, A Chen, E Sangalang, L Doyle, SS Rocha, ... PloS one 13 (8), e0201832, 2018 | 146 | 2018 |
Mechanisms controlling expression of the RAG locus during lymphocyte development TC Kuo, MS Schlissel Current opinion in immunology 21 (2), 173-178, 2009 | 140 | 2009 |
Preclinical evaluation of allogeneic CAR T cells targeting BCMA for the treatment of multiple myeloma C Sommer, B Boldajipour, TC Kuo, T Bentley, J Sutton, A Chen, T Geng, ... Molecular therapy 27 (6), 1126-1138, 2019 | 134 | 2019 |
Repression of BCL-6 is required for the formation of human memory B cells in vitro TC Kuo, AL Shaffer, J Haddad Jr, YS Choi, LM Staudt, K Calame The Journal of experimental medicine 204 (4), 819-830, 2007 | 128 | 2007 |
The restricted DH gene reading frame usage in the expressed human antibody repertoire is selected based upon its amino acid content J Benichou, J Glanville, ETL Prak, R Azran, TC Kuo, J Pons, C Desmarais, ... The Journal of Immunology 190 (11), 5567-5577, 2013 | 77 | 2013 |
Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 … NJ Lakhani, LQM Chow, JF Gainor, P LoRusso, KW Lee, HC Chung, ... The Lancet Oncology 22 (12), 1740-1751, 2021 | 76 | 2021 |
Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation MAJ Morgan, E Magnusdottir, TC Kuo, C Tunyaplin, J Harper, SJ Arnold, ... Molecular and cellular biology 29 (21), 5813-5827, 2009 | 70 | 2009 |
Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity TC Kuo, A Chen, O Harrabi, JT Sockolosky, A Zhang, E Sangalang, ... Journal of Hematology & Oncology 13, 1-19, 2020 | 65 | 2020 |
Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRPα J Sim, JT Sockolosky, E Sangalang, S Izquierdo, D Pedersen, ... MAbs 11 (6), 1036-1052, 2019 | 53 | 2019 |
Therapeutic antibodies and their uses TCC Kuo, JFC Riggers, W Chen, AS Chen, ED Pascua, TJ Van Blarcom, ... US Patent 9,969,809, 2018 | 49 | 2018 |
Constructs having a SIRP-α domain or variant thereof J Pons, L Deming, C Goodman, BJ Sim, SE Kauder, H Wan, TCC Kuo US Patent 10,259,859, 2019 | 46 | 2019 |
Chimeric antigen receptors targeting B-cell maturation antigen TCC Kuo, BA Boldajipour, JFC Riggers, P Duchateau, R Galetto, ... US Patent 10,294,304, 2019 | 45 | 2019 |