Comprehensive genomic characterization defines human glioblastoma genes and core pathways Cancer Genome Atlas Research Network Tissue source sites: Duke University ... Nature 455 (7216), 1061-1068, 2008 | 7598 | 2008 |
Integrated genomic analyses of ovarian carcinoma Cancer Genome Atlas Research Network Nature 474 (7353), 609, 2011 | 7108 | 2011 |
Mutational heterogeneity in cancer and the search for new cancer-associated genes MS Lawrence, P Stojanov, P Polak, GV Kryukov, K Cibulskis, ... Nature 499 (7457), 214-218, 2013 | 6017 | 2013 |
Age-related clonal hematopoiesis associated with adverse outcomes S Jaiswal, P Fontanillas, J Flannick, A Manning, PV Grauman, BG Mar, ... New England Journal of Medicine 371 (26), 2488-2498, 2014 | 4648 | 2014 |
The landscape of somatic copy-number alteration across human cancers R Beroukhim, CH Mermel, D Porter, G Wei, S Raychaudhuri, J Donovan, ... Nature 463 (7283), 899-905, 2010 | 4434 | 2010 |
Discovery and saturation analysis of cancer genes across 21 tumour types MS Lawrence, P Stojanov, CH Mermel, JT Robinson, LA Garraway, ... Nature 505 (7484), 495-501, 2014 | 3356 | 2014 |
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 DA Barbie, P Tamayo, JS Boehm, SY Kim, SE Moody, IF Dunn, ... Nature 462 (7269), 108-112, 2009 | 3345 | 2009 |
GISTIC2. 0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers CH Mermel, SE Schumacher, B Hill, ML Meyerson, R Beroukhim, G Getz Genome biology 12, 1-14, 2011 | 3155 | 2011 |
Pan-cancer patterns of somatic copy number alteration TI Zack, SE Schumacher, SL Carter, AD Cherniack, G Saksena, B Tabak, ... Nature genetics 45 (10), 1134-1140, 2013 | 2002 | 2013 |
EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer JP Koivunen, C Mermel, K Zejnullahu, C Murphy, E Lifshits, AJ Holmes, ... Clinical cancer research 14 (13), 4275-4283, 2008 | 1260 | 2008 |
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas AJ Bass, H Watanabe, CH Mermel, S Yu, S Perner, RG Verhaak, SY Kim, ... Nature genetics 41 (11), 1238-1242, 2009 | 1093 | 2009 |
Lin28 promotes transformation and is associated with advanced human malignancies SR Viswanathan, JT Powers, W Einhorn, Y Hoshida, TL Ng, S Toffanin, ... Nature genetics 41 (7), 843-848, 2009 | 965 | 2009 |
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity R Firestein, AJ Bass, SY Kim, IF Dunn, SJ Silver, I Guney, E Freed, ... Nature 455 (7212), 547-551, 2008 | 817 | 2008 |
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy J Barretina, BS Taylor, S Banerji, AH Ramos, M Lagos-Quintana, ... Nature genetics 42 (8), 715-721, 2010 | 811 | 2010 |
Prognostically relevant gene signatures of high-grade serous ovarian carcinoma RGW Verhaak, P Tamayo, JY Yang, D Hubbard, H Zhang, CJ Creighton, ... The Journal of clinical investigation 123 (1), 2012 | 677 | 2012 |
PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR ML Sos, M Koker, BA Weir, S Heynck, R Rabinovsky, T Zander, ... Cancer research 69 (8), 3256-3261, 2009 | 662 | 2009 |
Highly parallel identification of essential genes in cancer cells B Luo, HW Cheung, A Subramanian, T Sharifnia, M Okamoto, X Yang, ... Proceedings of the National Academy of Sciences 105 (51), 20380-20385, 2008 | 651 | 2008 |
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset CJ Ceol, Y Houvras, J Jane-Valbuena, S Bilodeau, DA Orlando, V Battisti, ... Nature 471 (7339), 513-517, 2011 | 632 | 2011 |
ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines JA Engelman, PA Jänne, C Mermel, J Pearlberg, T Mukohara, C Fleet, ... Proceedings of the National Academy of Sciences 102 (10), 3788-3793, 2005 | 615 | 2005 |
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer MJ Niederst, LV Sequist, JT Poirier, CH Mermel, EL Lockerman, ... Nature communications 6 (1), 6377, 2015 | 612 | 2015 |