Grant W Brown

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Charles BooneProfessor, Donnelly Centre, University of TorontoVerified email at utoronto.ca
Michael ChangEuropean Research Institute for the Biology of AgeingVerified email at umcg.nl
Michael Costanzouniversity of torontoVerified email at utoronto.ca
Brenda AndrewsDirector, The Donnelly Centre, University of TorontoVerified email at utoronto.ca
Corey NislowProfessor, CRC Tier 1 in Translational Genomics, University of British ColumbiaVerified email at ubc.ca
Anastasia BaryshnikovaPrincipal Investigator, Calico Life SciencesVerified email at calicolabs.com
Chad MyersUniversity of MinnesotaVerified email at umn.edu
Jessica Vaisica, Ph.D.Graduate Student, University of TorontoVerified email at mail.utoronto.ca
Zhaolei Zhang, ProfessorUniversity of Toronto, Donnelly Centre, Dept of Molecular Genetics, Dept of Computer ScienceVerified email at utoronto.ca
anne-claude gingrasLunenfeld-Tanenbaum Research Institute; University of TorontoVerified email at lunenfeld.ca
Timothy R. HughesUniversity of TorontoVerified email at utoronto.ca
Csanad Z. BachratiUniversity of LincolnVerified email at lincoln.ac.uk
TaeHyung Simon KimUniversity of TorontoVerified email at mail.utoronto.ca
Guri Nina GiaeverAssociate Professor, Faculty of Pharmaceutical Sciences, University of British ColumbiaVerified email at UBC.ca
Daniel DurocherThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and Department of MolecularVerified email at lunenfeld.ca
Marcus SmolkaCornell UniversityVerified email at cornell.edu
Ridhdhi DesaiHarvard Medical School, Beth Israel Deaconess Medical CenterVerified email at bidmc.harvard.edu
Jason MoffatSenior Scientist & Program Head, Genetics & Genome Biology, Sickkids Hospital; Professor, UofTVerified email at utoronto.ca
Michael RiffleUniversity of WashingtonVerified email at uw.edu
Jasper RineUC BerkeleyVerified email at berkeley.edu

Grant W Brown

University of Toronto

Verified email at utoronto.ca - Homepage

DNA Replication Genomic Instability


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Global mapping of the yeast genetic interaction network AHY Tong, G Lesage, GD Bader, H Ding, H Xu, X Xin, J Young, GF Berriz, ... science 303 (5659), 808-813, 2004	2561	2004
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map SR Collins, KM Miller, NL Maas, A Roguev, J Fillingham, CS Chu, ... Nature 446 (7137), 806-810, 2007	1033	2007
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways AB Parsons, RL Brost, H Ding, Z Li, C Zhang, B Sheikh, GW Brown, ... Nature biotechnology 22 (1), 62-69, 2004	768	2004
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress JM Tkach, A Yimit, AY Lee, M Riffle, M Costanzo, D Jaschob, JA Hendry, ... Nature cell biology 14 (9), 966-976, 2012	581	2012
Regulation of chromosome replication TJ Kelly, GW Brown Annual review of biochemistry 69 (1), 829-880, 2000	549	2000
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O’Neil, ND Santos, ... Nature communications 8 (1), 14432, 2017	538	2017
Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase S Nagai, K Dubrana, M Tsai-Pflugfelder, MB Davidson, TM Roberts, ... Science 322 (5901), 597-602, 2008	513	2008
Unification of protein abundance datasets yields a quantitative Saccharomyces cerevisiae proteome B Ho, A Baryshnikova, GW Brown Cell systems 6 (2), 192-205. e3, 2018	471	2018
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale A Baryshnikova, M Costanzo, Y Kim, H Ding, J Koh, K Toufighi, JY Youn, ... Nature methods 7 (12), 1017-1024, 2010	436	2010
A genetic map of the response to DNA damage in human cells M Olivieri, T Cho, A Álvarez-Quilón, K Li, MJ Schellenberg, ... Cell 182 (2), 481-496. e21, 2020	435	2020
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage M Chang, M Bellaoui, C Boone, GW Brown Proceedings of the National Academy of Sciences 99 (26), 16934-16939, 2002	360	2002
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates L Wu, CZ Bachrati, J Ou, C Xu, J Yin, M Chang, W Wang, L Li, GW Brown, ... Proceedings of the National Academy of Sciences 103 (11), 4068-4073, 2006	319	2006
Systematic analysis of complex genetic interactions E Kuzmin, B VanderSluis, W Wang, G Tan, R Deshpande, Y Chen, M Usaj, ... Science 360 (6386), eaao1729, 2018	289	2018
Mapping the cellular response to small molecules using chemogenomic fitness signatures AY Lee, RP St. Onge, MJ Proctor, IM Wallace, AH Nile, PA Spagnuolo, ... Science 344 (6180), 208-211, 2014	277	2014
The synthetic genetic interaction spectrum of essential genes AP Davierwala, J Haynes, Z Li, RL Brost, MD Robinson, L Yu, ... Nature genetics 37 (10), 1147-1152, 2005	276	2005
Identification of protein complexes required for efficient sister chromatid cohesion ML Mayer, I Pot, M Chang, H Xu, V Aneliunas, T Kwok, R Newitt, ... Molecular biology of the cell 15 (4), 1736-1745, 2004	274	2004
Regulation of the replication initiator protein p65 cdc18 by CDK phosphorylation PV Jallepalli, GW Brown, M Muzi-Falconi, D Tien, TJ Kelly Genes & development 11 (21), 2767-2779, 1997	235	1997
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability D Xu, R Guo, A Sobeck, CZ Bachrati, J Yang, T Enomoto, GW Brown, ... Genes & development 22 (20), 2843-2855, 2008	220	2008
Exploiting DNA replication stress for cancer treatment T Ubhi, GW Brown Cancer research 79 (8), 1730-1739, 2019	209	2019
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex M Chang, M Bellaoui, C Zhang, R Desai, P Morozov, L Delgado‐Cruzata, ... The EMBO journal 24 (11), 2024-2033, 2005	204	2005

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