Loss of PTEN promotes resistance to T cell–mediated immunotherapy W Peng, JQ Chen, C Liu, S Malu, C Creasy, MT Tetzlaff, C Xu, ... Cancer discovery 6 (2), 202-216, 2016 | 1429 | 2016 |
Increased tumor glycolysis characterizes immune resistance to adoptive T cell therapy T Cascone, JA McKenzie, RM Mbofung, S Punt, Z Wang, C Xu, ... Cell metabolism 27 (5), 977-987. e4, 2018 | 510 | 2018 |
BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice C Liu, W Peng, C Xu, Y Lou, M Zhang, JA Wargo, JQ Chen, HS Li, ... Clinical cancer research 19 (2), 393-403, 2013 | 413 | 2013 |
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HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes RM Mbofung, JA McKenzie, S Malu, M Zhang, W Peng, C Liu, I Kuiatse, ... Nature communications 8 (1), 451, 2017 | 129 | 2017 |
The RNA-binding protein MEX3B mediates resistance to cancer immunotherapy by downregulating HLA-A expression L Huang, S Malu, JA McKenzie, MC Andrews, AH Talukder, T Tieu, ... Clinical Cancer Research 24 (14), 3366-3376, 2018 | 94 | 2018 |
The effect of topoisomerase I inhibitors on the efficacy of T-cell-based cancer immunotherapy JA McKenzie, RM Mbofung, S Malu, M Zhang, E Ashkin, S Devi, ... JNCI: Journal of the National Cancer Institute 110 (7), 777-786, 2018 | 81 | 2018 |
Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma W Peng, LJ Williams, C Xu, B Melendez, JA McKenzie, Y Chen, ... Clinical Cancer Research 25 (21), 6406-6416, 2019 | 43 | 2019 |
Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators J Hou, Y Wang, L Shi, Y Chen, C Xu, A Saeedi, K Pan, R Bohat, NA Egan, ... Journal for immunotherapy of cancer 9 (2), 2021 | 30 | 2021 |
Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity S Punt, S Malu, JA McKenzie, SZ Manrique, EM Doorduijn, RM Mbofung, ... Cancer Immunology, Immunotherapy 70, 1101-1113, 2021 | 21 | 2021 |
Loss of PTEN promotes resistance to T cell-mediated immunotherapy. Cancer Discov. 2016; 6 (2): 202–16 W Peng, JQ Chen, C Liu, S Malu, C Creasy, MT Tetzlaff External Resources Crossref (DOI), 0 | 17 | |
CpG-based immunotherapy impairs antitumor activity of BRAF inhibitors in a B-cell-dependent manner L Huang, Z Wang, C Liu, C Xu, RM Mbofung, JA McKenzie, H Khong, ... Oncogene 36 (28), 4081-4086, 2017 | 12 | 2017 |
Genetic ablation of adhesion ligands averts rejection of allogeneic immune cells Q Hammer, K Perica, H van Ooijen, R Mbofung, P Momayyezi, E Varady, ... bioRxiv, 2023.10. 09.557143, 2023 | 4 | 2023 |
Combined genetic ablation of CD54 and CD58 in CAR engineered cytotoxic lymphocytes effectively averts allogeneic immune cell rejection Q Hammer, K Perica, RM Mbofung, H van Ooijen, E Varady, M Jelcic, ... Blood 140 (Supplement 1), 1165-1166, 2022 | 4 | 2022 |
Alloimmune defense receptor harnesses host immune cell activation to potentiate functional persistence and anti-tumor activity of off-the-shelf, cell-based cancer therapy AM Williams, KL Hayama, Y Pan, B Groff, RM Mbofung, A Chang, C Chen, ... Blood 140 (Supplement 1), 4547-4548, 2022 | 4 | 2022 |
117 FT536 path to IND: ubiquitous targeting of solid tumors with an off-the-shelf, first-of-kind MICA/B-specific CAR-iNK cellular immunotherapy J Goulding, B Hancock, R Blum, M Ge, S Gaidarova, P Rogers, ... Journal for ImmunoTherapy of Cancer 9 (Suppl 2), 2021 | 4 | 2021 |
A novel stealth strategy that activates adoptively transferred allogeneic immune cells and avoids rejection for off-the-shelf cell-based cancer therapy AM Williams, K Hayama, Y Pan, B Groff, RM Mbofung, L Fong, ... Blood 138, 4800, 2021 | 2 | 2021 |
Combination of topoisomerase-I inhibitors with immunotherapy in the treatment of cancer P Hwu, JA Mckenzie, RM Mbofung, R Amaria US Patent 10,894,044, 2021 | 2 | 2021 |
Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies Q Hammer, K Perica, RM Mbofung, H van Ooijen, KE Martin, ... Cell Stem Cell 31 (9), 1376-1386. e8, 2024 | 1 | 2024 |
iPSC-derived CD38-null NK cells in combination with CD38-targeted antibody: a dual therapeutic strategy to enable ADCC and eliminate host immune cells in multiple myeloma RM Mbofung, X Zong, E Varady, AM Williams, KL Hayama, Y Pan, ... Blood 140 (Supplement 1), 7388-7389, 2022 | 1 | 2022 |